Xinqiao Jia, Ph.D.
590 Avenue 1743
Newark, DE 19713
- Postdoctoral Researcher, Chemical Engineering, 2002-2005, MIT
- Ph.D., Polymer Science and Engineering, 2002, University of Massachusetts, Amherst
- M.S., Macromolecular Chemistry and Physics, 1998, Fudan University, China
- B.S., Applied Chemistry, 1995, Fudan University, China
- Bioorthogonal chemistry
- Tissue engineering
- Disease modeling
- Drug delivery
AREAS OF SPECIAL INTEREST
Our research lies at the interface of materials and biology. We are interested in developing intelligent biomaterials that closely mimic the molecular composition, biological functions, mechanical responsiveness and multiscale organizations of the natural extracellular matrices. These synthetic matrices are constructed using diverse and modular building blocks employing highly efficient bio-orthogonal coupling chemistries in conjunction with concerted supramolecular interactions. Examples of these materials are hyaluronic acid–based microgels and doubly crosslinked networks, mechano–responsive hydrogels crosslinked by block copolymer micelles and peptide/polymer multiblock hybrid copolymers. These materials, combined with defined mechanical cues and biological factors, create a three-dimensional microenvironment for improved understanding of cell biology. Using biologically inspired paradigms, we are developing methodologies for the engineering of healthy, replacement tissues such as cartilage, vocal folds and salivary glands, as well as disease models, such as prostate cancer tumor spheroids.
For a complete publication list, check Dr. Jia’s Google Scholar.
Fowler, E. W.; Ravikrishnan, A.; Witt, R. L.; Pradhan-Bhatt, S.; Jia, X.*“RGDSP–Decorated Hyaluronate Hydrogels Facilitate Rapid 3D Expansion of Amylase–Expressing Salivary Gland Progenitor Cells” ACS Biomat. Sci. & Eng., 2021, 7, 5749–5761.
Wang, C.; Zhang, H.; Zhang, T.; Zou, X.; Wang, H.; Rosenberger, J.; Vannam, R.; Trout, W.; Grimm, J. B.; Lavis, L. D.; Thorpe, C.; Jia, X.*; Li, Z.*; Fox, J. M.* “Enabling in vivo Photocatalytic Activation of Rapid Bioorthogonal Chemistry by Repurposing Si–Rhodamine Fluorophores as Cytocompatible Far–Red Photocatalysts” Am. Chem. Soc., 2021, 143, 10793–10803.
Dicker, K. T.; Moore, A. C.; Garabedian, N. T.; Zhang, H.; Scinto, S. L.; Akins, R. E.; Burris, D. L.; Fox, J. M.*; Jia, X.*“Spatial Patterning of Molecular Cues and Vascular Cells in Fully Integrated Hydrogel Channels via Interfacial Bioorthogonal Crosslinking” ACS Appl. Mater. Interfaces, 2019, 11, 16402–16411.
Hao, Y.; Song, J.; Ravikrishnan, A.; Dicker, K. T.; Fowler, E. W.; Zerdoum, A. B.; Li, Y.; Zhang, H.; Rajasekaran, A. K.; Fox, J. M.*; Jia, X.*“Rapid Bioorthogonal Chemistry Enables in Situ Modulation of the Stem Cell Behavior in 3D without External Triggers” ACS Appl. Mater. Interfaces, 2018, 10, 26016–26027.
Liu, S.; Moore, A. C.; Zerdoum, A. B.; Zhang, H.; Scinto, S. L.; Zhang, H.; Gong, L.; Burris, D. L.; Rajasekaran, A. K.; Fox, J. M;* Jia, X.*“Cellular Interactions with Hydrogel Microfibers Synthesized via Interfacial Tetrazine Ligation” Biomaterials, 2018, 180, 24–35
Dicker, K. T.; Song, J.; Moore, A. C.; Zhang, H.; Li, Y.; Burris, D. L.; Jia, X.*and Fox, J. M.* “Core–Shell Patterning of Synthetic Hydrogels Via Interfacial Bioorthogonal Chemistry for Spatial Control of Stem Cell Behavior” Science. 2018, 9, 5394–5404.
Ozdemir, T.; Srinivasan, P. P.; Zakheim, D. R.; Harrington, D. A.; Witt, R. L.; Farach–Carson, M. C.; Jia, X.*; Pradhan–Bhatt, S.* “Bottom–up Assembly of Salivary Gland Microtissues for Assessing Myoepithelial Cell Function”, Biomaterials, 2017, 142, 124–135.
Liu, S.; Zhang, H.; Remy, R. A.; Deng, F.; Mackay, M. E.; Fox, J. M.*; Jia, X.*“Meter–Long Multiblock Copolymer Microfibers via Interfacial Bioorthogonal Polymerization”, Mater., 2015, 27, 2783–2790.
Tong, Z.; Zerdoum, A. B.; Duncan, R. L.; Jia, X.*“Dynamic Vibration Cooperates with Connective Tissue Growth Factor to Modulate Stem Cell Behaviors”, Tissue Eng Part A, 2014, 20, 1922–1934.
Xu, X.; Sabanayagam, C. R.; Harrington, D. A.; Farach–Carson, M. C.; Jia, X.*“A Hydrogel–Based Tumor Model for the Evaluation of Nanoparticle–Based Cancer Therapeutics”, Biomaterials, 2014, 35, 3319–3330.