A paper co-authored by Emily Day, “miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma”, has been selected as the cover of an upcoming issue of Genes & Development. The paper identifies a small RNA molecule called miR-182 that can suppress cancer-causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor. The researchers used nanoparticles called spherical nucleic acids to safely deliver miR-182 across the blood-brain/blood-tumor barriers to reach tumor cells where they directly suppressed multiple oncogenes at once, increasing cancer cell death, reducing tumor growth, and improving overall survival. This approach offers a novel strategy for therapeutic intervention in GBM.
- Kiick and Price labs awarded R01 from the National Institutes of HealthThanks to a five-year, $3 million research grant, a team of UD engineers will develop approaches to improve delivery of therapeutics to treat post-traumatic osteoarthritis.
- Orthopedics in actionUD Engineering’s Jenni Buckley develops orthopedics curriculum for high school students.
- Doctoral Dissertation Defense – Mackenzie ScullyBME PhD Candidate Mackenzie Scully will be defending their dissertation: Engineering Cancer Cell Membrane-Wrapped Nanoparticles for Targeted Delivery of Cancer Therapeutics
- Doctoral Dissertation Defense – Zheng CaoDate: Thursday, September 7, 2023 Time: 9:30 am
- Doctoral Dissertation Defense – Wade StewartBME PhD Candidate Wade Stewart will be defending their dissertation: Implementation of static and dynamic culture substrates to control maturation of human induced pluripotent stem cell cardiomyocytes through tunable manipulation of topographical roughness and bulk stiffness.