John Slater, Ph.D.
5 Innovation Way
Suite 200, Office 151
Newark, DE 19716
- Ph.D. Biomedical Engineering. Doctoral Portfolio Degree in Nanotechnology. University of Texas at Austin.
- B.S. Mechanical Engineering. University of North Carolina at Charlotte.
- Cell Engineering
- Tissue Engineering
AREAS OF SPECIAL INTEREST
It is well established that microenvironmental cues influence cell fate but the molecular mechanisms that drive this phenomenon remain elusive and the ability to precisely control a cell’s local environment remains difficult. The Slater Lab focuses on the development and implementation of new fabrication methodologies to create biomimetic patterned surfaces and 3D multicellular constructs that allow for precise control over the presentation of both biophysical and biochemical cues that can be tuned to elicit desired cellular traits. The lab is applying these highly structured biomaterials to a number of topics including the recapitulation of desired cellular phenotypes, reduction of cellular heterogeneity in culture, lineage-specific stem cell differentiation, and development of high-throughput drug screening models.
- O.A. Banda, K.A. Heintz, H.T Nie, and J.H. Slater. “Biomimetic Surfaces for Cell Engineering.” In: M. Zhang, R.R. Naik, and L. Dai, editors. Carbon Nanomaterials for Biomedical Applications, Chapter 18. 543-569. Springer International Publishing (2016).
- C.W. Hu, S.M. Kornblau, J.H. Slater & A.A. Qutub. “Progeny Clustering: a Method to Identify Biological Phenotypes.” Scientific Reports. 5, 12894 (2015).
- J.H. Slater, J.C. Culver, B.L. Long, C.W. Hu, J.Hu, T.F. Birk, A.A. Qutub, M.E. Dickinson, & J.L. West. “Recapitulation and Modulation of the Cellular Architecture of a User-Chosen Cell of Interest Using Cell-Derived, Biomimetic Patterning.” ACS Nano. 9, 6128–6138 (2015).
- J.H. Slater, P.J. Boyce, M.P. Jancaitis, H.E. Gaubert, A.L. Chang, M.K. Markey, and W. Frey. “Modulation of Endothelial Cell Migration via Manipulation of Adhesion Site Growth Using Nanopatterned Surfaces.” ACS Applied Materials and Interfaces. 7, 4390-4400 (2015).
- J.H. Slater and J.L West. “Fabrication of Multifaceted, Micropatterned Surfaces and Image-Guided Patterning Using Laser Scanning Lithography.” In: M. Piel and T. Théry, editors. Micropatterning in Cell Biology Part A, Vol 119. 193-217. Methods in Cell Biology, Elsevier Academic Press (2014).
- J.C. Culver, J.C. Hoffmann, R.A. Poché, J.H. Slater, J.L. West, and M.E. Dickinson. “Three-Dimensional Biomimetic Patterning in Hydrogels to Guide Cellular Organization.” Advanced Materials. 24, 2344-2348 (2012).
- J.H. Slater, J.S. Miller, S.S. Yu, and J.L. West. “Fabrication of Multifaceted Micropatterned Surfaces with Laser Scanning Lithography.” Advanced Functional Materials. 21, 2876-2888 (2011).
- K.I. McConnell, J.H. Slater, A. Han, J.L. West, and J. Suh. “Microcontact Printing for Co-Patterning Cells and Viruses for Spatially Controlled Substrate-Mediated Gene Delivery.” Soft Matter. 7, 4993-5001 (2011).
- E.S. Day, L.R. Bickford, J.H. Slater, N.S. Riggall, R.A. Drezek, and J.L. West. “Antibody-Conjugated Gold-Gold Sulfide Nanoparticles as Multifunctional Agents for Imaging and Therapy of Breast Cancer.” Int. J. Nanomedicine. 5, 445-454 (2010).
- J.H. Slater and W. Frey. “Nanopatterning of Fibronectin and the Influence of Integrin Clustering on Endothelial Cell Spreading and Proliferation.” J. Biomed. Mater. Res. Part A. 87A, 176-195 (2008).
- J.H. Slater, S. Jain, R.N. Coger, and C.Y. Lee. “The Effects of Shear Stress on Endothelial Cells at Hypothermic Temperatures.” American Society of Mechanical Engineers, Bioengineering Division. 54, 219-225 (2002).