A paper co-authored by Emily Day, “miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma”, has been selected as the cover of an upcoming issue of Genes & Development. The paper identifies a small RNA molecule called miR-182 that can suppress cancer-causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor. The researchers used nanoparticles called spherical nucleic acids to safely deliver miR-182 across the blood-brain/blood-tumor barriers to reach tumor cells where they directly suppressed multiple oncogenes at once, increasing cancer cell death, reducing tumor growth, and improving overall survival. This approach offers a novel strategy for therapeutic intervention in GBM.

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